Type II collagen expression in a rabbit model of developmental dysplasia of the hip

doi:10.3969/j.issn.2095-4344.2015.49.002

Abstract

Abstract:

BACKGROUND: Mild developmental dysplasia of hip causes high morbidity of osteoarthritis on adults. It is thought that change of collagen and proteoglycans in cartilage may be the direct reasons for osteoarthritis.
OBJECTIVE: To observe the changes in the expressions of type II collagen of acetabular cartilage in a rabbit model of early developmental dysplasia of hip.
METHODS: Left lower extremity served as experimental side and right one as control. The rabbit model of developmental dysplasia of hip was successfully established by applying the method of knee extending and fixing with cylinder cast.
RESULTS AND CONCLUSION: Local chondrocyte clusters were visible in acetabular cartilage on the experimental side. Toluidine blue staining loss was observed in extracellular matrix. Moreover, the number of type II collagen-positive cells and type II collagen expression were higher in the experimental side than in the control side. These results indicate that type II collagen expression may be associated with cartilage degeneration.
中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

CLC Number:

R318

Zhang Xiang-xin, Chen Guang-xiang, Cheng Liang, Xu Ren-jie, Zou Tian-ming. Type II collagen expression in a rabbit model of developmental dysplasia of the hip[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(49): 7879-7884.

Figures/Tables 3

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